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Herceptin 研发史
Slamon et al.
Science
HER2 gene
amplification
Cloning of in Breast Cancer
EGFR cDNA and correlation Phase III
Relation to with disease Phase I Approval
V-erbB Rhu MAb In Europe
progression
1984 1987 1992 1995 2000
1985 1989 1993 1998 2002
HER2 Hudziak et al. Phase II FDA MAb 2C4
Sequence published MCB Approval In
Coussens et al. Anti-tumor effect Development
of MAb 4D5 and 2C4
